Two of the questions from the IIEF served as primary study endpoints; categorical responses were elicited to questions about (1) the ability to achieve erections sufficient for sexual intercourse and (2) the maintenance of erections after penetration. The

Two of the questions from the IIEF served as primary study endpoints; categorical responses were elicited to questions about (1) the ability to achieve erections sufficient for sexual intercourse and (2) the maintenance of erections after penetration. The

In a study of healthy male volunteers, Fildena (100 mg) did not affect the steady state pharmacokinetics of the HIV protease inhibitors, saquinavir and ritonavir, both of which are CYP3A4 substrates. Given Fildena peak plasma concentrations of approximately 1 μM after recommended doses, it is unlikely that VIAGRA will alter the clearance of substrates of these isoenzymes. In a study of healthy male volunteers, co-administration of Fildena at steady state (80 mg t.i.d.) with endothelin receptor antagonist bosentan (a moderate inducer of CYP3A4, CYP2C9 and possibly of CYP2C19) at steady state (125 mg b.i.d.) resulted in a 63% decrease of Fildena AUC and a 55% decrease in Fildena Cmax Concomitant administration of strong CYP3A4 inducers, such as rifampin, is expected to cause greater decreases in plasma levels of Fildena.

 

Population pharmacokinetic data from patients in clinical trials also indicated a reduction in Fildena clearance when it was co-administered with CYP3A4 inhibitors (such as ketoconazole, erythromycin, or cimetidine) see DOSAGE AND ADMINISTRATION and DRUG INTERACTIONS. When a single 100 mg dose of VIAGRA was administered with erythromycin, a moderate CYP3A4 inhibitor, at steady state (500 mg bid for 5 days), there was a 160% increase in Fildena Cmax and a 182% increase in Fildena AUC. Cimetidine (800 mg), a nonspecific CYP inhibitor, caused a 56% increase in plasma Fildena concentrations when co-administered with VIAGRA (50 mg) to healthy volunteers.

 

Mean Fildena plasma concentrations measured after the administration of a single oral dose of 100 mg to healthy male volunteers is depicted below: There was no effect on sperm motility or morphology after single 100 mg oral doses of VIAGRA in healthy volunteers. At single oral doses of 100 mg and 200 mg, transient dose-related impairment of color discrimination was detected using the Farnsworth-Munsell 100-hue test, with peak effects near the time of peak plasma levels.

 

Table 3: Hemodynamic Data in Patients with Stable Ischemic Heart Disease after Intravenous Administration of 40 mg of Fildena. The maximum observed decrease in diastolic blood pressure was -17.2 mmHg when Fildena was co-administered with alcohol versus -11.1 mmHg when alcohol was administered alone. The maximum observed decrease in systolic blood pressure was -18.5 mmHg when Fildena was co-administered with alcohol versus -17.4 mmHg when alcohol was administered alone.

 

VIAGRA (50 mg) did not potentiate the hypotensive effect of alcohol (0.5 g/kg) in healthy volunteers with mean maximum blood alcohol levels of 0.08%.https://generico-farmacia.eu/

Il Comitato Processione Venerdì Santo

ringrazia la famiglia Aviani e la famiglia Centoscudi, per la disponibilità dei terreni senza i quali la Sacra Rappresentazione non sarebbe così suggestiva.
Un ringraziamento allo Studio GSG di Bagnoregio e a Mario Mecarelli per le fotografie utilizzate.
Si ringrazia inoltre chi direttamente o indirettamente contribuisce alla realizzazione dell'evento ed un grazie particolare va a tutta la comunità di Vetriolo che da anni partecipa sentitamente alla Rappresentazione del Venerdì Santo.

 

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